Intraoperative Opioid-Free Anesthesia with Dexmedetomidine and Esketamine Versus Conventional General Anesthesia in Laparoscopic Cholecystectomy at 3,600 m: A Randomized Trial on Hemodynamic Stability and Postoperative Recovery
At high altitudes, OFA with dexmedetomidine and esketamine exhibited distinct clinical characteristics compared with opioid-based anesthesia, maintaining blood pressure and postoperative analgesia but less effectively blunting intubation-induced pressor responses and prolonging awakening time. These factors should be weighed when selecting anesthesia strategies in resource-limited, high-altitude settings, particularly when managing large numbers of patients.
Authors
- Lei Zhang (ORCID: https://orcid.org/0000-0001-5559-6292)
- Tu Ke
- Hua Huang (ORCID: https://orcid.org/0000-0003-2587-1702)
- Lei Tian (ORCID: https://orcid.org/0000-0002-1929-3953)
- Kun Bai (ORCID: https://orcid.org/0000-0003-4716-3774)
- H. J. Li (ORCID: https://orcid.org/0000-0002-4257-6994)
- Xiaojun Li (ORCID: https://orcid.org/0000-0002-5136-8660)
- Mengmei Fu
- Lin Li (ORCID: https://orcid.org/0000-0003-3867-0758)
- Qi Zhu (ORCID: https://orcid.org/0000-0002-0021-3757)
- Zhuo Zhan
- Mengxia Wang (ORCID: https://orcid.org/0000-0002-6141-2418)
- Mingming Zhang (ORCID: https://orcid.org/0000-0003-4677-5664)
- Cheng Jiang (ORCID: https://orcid.org/0000-0003-4386-0740)
- Ruofan Yi (ORCID: https://orcid.org/0000-0001-5818-1682)
Institutions
- 117th Hospital of People's Liberation Army (CN)
- General Hospital of Jinan Military Command (CN)
- Department of Embryology (US)
- Xijing Hospital (CN)
Publication Details
- Journal
- High Altitude Medicine & Biology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1177/15578682251381135
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00