Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ <sup>9</sup> ‐tetrahydrocannabinol in older patients with poor appetite
The parent-metabolite model describes and quantifies the pharmacokinetics of oromucosally administered THC in older medical patients with poor appetite. The covariate analysis did not show any clinically significant effect on pharmacokinetic parameters of THC or THC-OH.
Authors
- Helle Gybel Juul‐Larsen (ORCID: https://orcid.org/0000-0002-8543-9201)
- Rikke Lundsgaard Nielsen (ORCID: https://orcid.org/0000-0003-2208-7349)
- Louise Westberg Strejby Christensen (ORCID: https://orcid.org/0009-0006-8954-2675)
- Ove Andersen (ORCID: https://orcid.org/0000-0002-2274-548X)
- Aino Leegaard Andersen (ORCID: https://orcid.org/0000-0003-1449-1931)
- Torben Breindahl (ORCID: https://orcid.org/0000-0001-8166-1983)
- Trine Meldgaard Lund (ORCID: https://orcid.org/0000-0001-8598-2880)
- Baker Nawfal Jawad (ORCID: https://orcid.org/0000-0002-6915-744X)
- Izzet Altintas (ORCID: https://orcid.org/0000-0001-6790-2218)
- Olivia Bornæs (ORCID: https://orcid.org/0000-0002-5748-8153)
- Ida Klitzing Storgaard (ORCID: https://orcid.org/0000-0001-8650-6595)
- Lillian Mørch Jørgensen (ORCID: https://orcid.org/0000-0002-0199-1577)
- Morten Baltzer Houlind
Institutions
- University of Copenhagen (DK)
- Amager Hospital (DK)
- Copenhagen University Hospital (DK)
- North Denmark Region (DK)
- The Capital Region Pharmacy (DK)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1002/bcp.70284
- Citations
- 2
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79