Pregnenolone sulfate enables synapse‐specific metaplastic gating of heterosynaptic GABAergic plasticity

Our findings demonstrate that neurosteroids can selectively shape synaptic integration across distinct inhibitory circuits and metaplastically regulate excitatory-inhibitory co-plasticity in an input-specific manner. By uncovering synapse-specific and intersynaptic mechanisms of neurosteroid action, our study provides new insights into how inhibitory circuit dynamics are fine-tuned to support network stability and learning.