Multiple patient-derived glioblastoma models reveal synthetic lethality through concurrent PI3K and CDK4/6 inhibition by blocking trans-active cooperation
Employing multiple patient-derived models, our study uncovers clinically relevant PI3Ki resistance mechanisms and advocates a rationale for synthetic lethality through combined PI3K-CDK4/6 inhibition, offering substantial therapeutic potential for GBM patients.
Authors
- Junyu Yang (ORCID: https://orcid.org/0000-0002-7795-7711)
- Jingzhe Wang (ORCID: https://orcid.org/0000-0001-8332-7997)
- Siyi Xu (ORCID: https://orcid.org/0000-0002-5147-2644)
- Tongjie Ji
- Meng Cheng
- Yuntong Yang (ORCID: https://orcid.org/0000-0003-3611-5443)
- Honghao Wang (ORCID: https://orcid.org/0000-0002-2030-180X)
- Ying Pang (ORCID: https://orcid.org/0000-0001-6195-2150)
- Han Xie
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Min Liu (ORCID: https://orcid.org/0000-0002-1626-7100)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-2488-5021)
- Xu Chen (ORCID: https://orcid.org/0000-0003-4303-8116)
- Zhigang Wang (ORCID: https://orcid.org/0000-0003-4149-0862)
- Chunyu Zhang (ORCID: https://orcid.org/0000-0003-0448-1756)
- Chunlong Zhong (ORCID: https://orcid.org/0000-0002-0605-7273)
- Yueyao Wu
Institutions
- Tongji University (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1093/neuonc/noaf224
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00