<i>In vitro</i> evolution provides insights into mechanisms of <i>Mycoplasma genitalium</i> resistance to moxifloxacin
Mutations in multiple genes conferring fluoroquinolone resistance appeared with regularity in vitro. Findings of an additive effect for ParC/GyrA changes, and greater effectiveness of sitafloxacin against resistant bacteria compared with moxifloxacin, are both consistent with clinical data. Improved understanding of fluoroquinolone resistance will inform the development of diagnostic assays predicting fluoroquinolone susceptibility.
Authors
- Gerald L. Murray (ORCID: https://orcid.org/0000-0003-3330-4433)
- Jose L. Huaman (ORCID: https://orcid.org/0000-0003-1321-887X)
- Dorothy A. Machalek (ORCID: https://orcid.org/0000-0002-4101-8085)
- Jennifer Danielewski (ORCID: https://orcid.org/0000-0002-6776-9194)
- Michael J. McDonald (ORCID: https://orcid.org/0000-0002-5735-960X)
- Catriona S. Bradshaw (ORCID: https://orcid.org/0000-0002-6643-5678)
- Teck-Phui Chua (ORCID: https://orcid.org/0000-0002-7495-6529)
- Suzanne M Garland
Institutions
- Royal Women's Hospital (AU)
- The University of Melbourne (AU)
- UNSW Sydney (AU)
- Melbourne Sexual Health Centre (AU)
- Murdoch Children's Research Institute (AU)
- Melbourne Health (AU)
- Alfred Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1093/jac/dkaf324
- Citations
- 1
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- University of Melbourne