Distinct Retrotransposon Transcriptome in Pediatric Crohn’s Disease
Retrotransposon transcriptome in children with CD significantly differed from non-IBD controls in ileal biopsies with 15 retrotransposon loci consistently downregulated in CD. The possible regulatory function of these retrotransposon loci merits additional research. This study may provide valuable perspectives for the advancement of novel therapeutic strategies.
Authors
- Colton McNinch
- Ashleigh Sutton
- Eve May
- Shira Levy (ORCID: https://orcid.org/0009-0005-8240-925X)
- Diana Jo
- Suchitra K. Hourigan (ORCID: https://orcid.org/0000-0003-2656-5694)
- Anal Patel
- Rajendra Prasad (ORCID: https://orcid.org/0000-0002-1627-6699)
- Phoebe LaPoint
- Brynn O’Laughlin
- Qing Chen (ORCID: https://orcid.org/0000-0002-2088-0370)
- Galina Koroleva
Institutions
- National Institutes of Health (US)
- National Human Genome Research Institute (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-25
- DOI
- https://doi.org/10.1093/ibd/izaf190
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00