Successful treatment of Hailey–Hailey disease with oral roflumilast
Hailey–Hailey disease (HHD) is a rare autosomal dominant acantholytic disorder. It presents in adolescence or early adulthood with papulovesicular lesions that often coalesce into fissured or macerated erythematous plaques at the skin folds. The condition has a profound impact on quality of life and consensus on its optimal management is lacking. We report the first case of successful treatment with off-label oral roflumilast.
Authors
- Carlo Alberto Maronese (ORCID: https://orcid.org/0000-0002-9449-849X)
- Stefano Buffon (ORCID: https://orcid.org/0000-0001-6929-7947)
- Angelo Valerio Marzano (ORCID: https://orcid.org/0000-0002-2258-8357)
- Federica Derlino
- Giovanni Genovese (ORCID: https://orcid.org/0000-0002-7636-958X)
- Francesca Boggio (ORCID: https://orcid.org/0000-0003-2313-9585)
- Lorenzo Di Sarno (ORCID: https://orcid.org/0000-0002-4837-9297)
- Davide Termini (ORCID: https://orcid.org/0009-0004-1950-3780)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1093/ced/llaf422
- Primary Topic
- Genetic and rare skin diseases.
- Type
- article
- Field-Weighted Citation Impact
- 0.00