Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma
This study provides further insights into stemness-hypoxia interaction in HCC and delivers a clinically applicable predictive tool for prognosis. BI2536's synergy potential and the therapeutic value of G6PD targeting in stemness regulation advance individualized therapeutic strategies for HCC.
Authors
- Mingwei Gao (ORCID: https://orcid.org/0000-0002-5612-4251)
- Sunbin Ling (ORCID: https://orcid.org/0000-0003-0846-5489)
- Peiru Zhang (ORCID: https://orcid.org/0000-0002-5896-8511)
- Binwen Sun (ORCID: https://orcid.org/0000-0001-5360-4439)
- Jin Liu
- Jianhui Wu (ORCID: https://orcid.org/0000-0001-9416-8952)
- Kun Guo (ORCID: https://orcid.org/0000-0002-5849-6876)
- Liming Wang (ORCID: https://orcid.org/0000-0001-7995-6037)
- Yuechuan Liu (ORCID: https://orcid.org/0009-0008-2350-0880)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1669275
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94