Cholesterol modulates trafficking of galanin receptor subtype 1 but not subtype 2: Insights from live‐cell imaging
Cholesterol selectively modulates GALR1 trafficking and ligand interactions, whereas GALR2 operates independently of cholesterol, revealing distinct regulatory mechanisms for each receptor subtype. These findings provide new insights into the interplay between membrane composition and receptor function, with potential implications for developing targeted therapies for galanin-related disorders.
Authors
- Sho Oasa (ORCID: https://orcid.org/0000-0003-3800-590X)
- Lars Terenius (ORCID: https://orcid.org/0000-0003-2880-9576)
- Vladana Vukojević (ORCID: https://orcid.org/0000-0003-0873-5653)
- Qing Xu (ORCID: https://orcid.org/0000-0002-0387-7559)
- Yi Tang (ORCID: https://orcid.org/0000-0002-8052-065X)
- Per Svenningsson (ORCID: https://orcid.org/0000-0001-6727-3802)
- Yutao Yang (ORCID: https://orcid.org/0000-0002-6835-2964)
- Tomas Hökfelt
- Tianyi Li (ORCID: https://orcid.org/0000-0002-7161-0987)
- Hui Li (ORCID: https://orcid.org/0000-0002-1973-3074)
- Yuping Bai (ORCID: https://orcid.org/0000-0003-2806-3110)
Institutions
- Karolinska University Hospital (SE)
- Capital Medical University (CN)
- Karolinska Institutet (SE)
- Chinese Institute for Brain Research (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/bph.70192
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00