RNA Pol II Inhibition Induces Death Independent of Transcription Loss

Major Finding: RNA polymerase II (RNA Pol II) suppression does not cause cell death due to mRNA and protein decay but instead actively triggers apoptosis via a previously uncharacterized pathway.Concept: Loss of hypophosphorylated RNA Pol II promotes PTBP1-mediated BCL2L12 translocation from the nucleus to the mitochondria, inducing apoptosis.Impact: This study uncovers the mechanism by which RNA Pol II loss drives the lethality of existing anticancer drugs, thereby motivating improved therapeutic approaches.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-084
Primary Topic
RNA Research and Splicing
Type
article
Field-Weighted Citation Impact
0.00
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article

RNA Pol II Inhibition Induces Death Independent of Transcription Loss

Cancer Discovery
RNA Research and Splicing
article

RNA Pol II Inhibition Induces Death Independent of Transcription Loss

article en

Abstract

Major Finding: RNA polymerase II (RNA Pol II) suppression does not cause cell death due to mRNA and protein decay but instead actively triggers apoptosis via a previously uncharacterized pathway.Concept: Loss of hypophosphorylated RNA Pol II promotes PTBP1-mediated BCL2L12 translocation from the nucleus to the mitochondria, inducing apoptosis.Impact: This study uncovers the mechanism by which RNA Pol II loss drives the lethality of existing anticancer drugs, thereby motivating improved therapeutic approaches.

Cancer Discovery
Openalex Percentile: Top 77%
RNA Research and Splicing
DOISourceOpenAlex
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RNA Pol II Inhibition Induces Death Independent of Transcription Loss · Cancer Discovery (2025) | TGRS Research Map | TGRS