Resurrecting Network and Systems Medicine

Network and Systems Medicine returns at a time when the discipline has advanced from conceptual foundations to demonstrated translational impact. Network pharmacology and systems approaches now provide clinical proof-of-concept, including synergistic interventions in ischemic stroke, mechanistic stratification of hypertension, and nutritional targeting in peripheral artery disease. These examples illustrate a shift from describing biological complexity to addressing causal mechanisms. Supported by initiatives such as REPO4EU and highlighted at RExPO’25, the journal will serve as a diamond open-access platform for sharing computational models, multi-omics integration, and drug repurposing strategies. Its mission is to accelerate collaboration and innovation across stakeholders and ensure that systems and network medicine deliver tangible patient benefit.