Modelling of the Systemic Inflammatory Host Response in Relation to the Microbiome of the Endodontic Infection
This study provides novel insights into the systemic immune profile of individuals with AP. IL-4 and bone metabolism markers may serve as potential biomarkers for distinguishing AP status. Our findings support the relevance of systemic inflammation in endodontic infections and underscore the value of multi-marker, multivariate approaches to better characterise disease progression and host-microbiome interactions. Such insights could contribute to improved risk stratification and personalised management in dental and systemic health contexts.
Authors
- Johan A. Westerhuis (ORCID: https://orcid.org/0000-0002-6747-9779)
- Suzette V. van der Waal (ORCID: https://orcid.org/0000-0002-6407-3714)
- Athina Christina Georgiou (ORCID: https://orcid.org/0000-0001-7198-5909)
- Bernd W. Brandt (ORCID: https://orcid.org/0000-0002-1155-1989)
- Anna Heintz‐Buschart (ORCID: https://orcid.org/0000-0002-9780-1933)
- Age K. Smilde (ORCID: https://orcid.org/0000-0002-3052-4644)
- Geert Roelof van der Ploeg (ORCID: https://orcid.org/0009-0007-5204-3386)
Institutions
- Academic Center for Dentistry Amsterdam (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/iej.70023
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00