Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status

These findings suggest that the developmental stage of the blastocyst is the primary determinant of successful outcomes in BCT-associated RPL, whereas embryo morphological grading predominantly influences pregnancy outcomes in RPL patients with normal karyotypes. These results highlight the importance of personalized embryo selection strategies based on parental chromosomal status and embryological characteristics to optimize reproductive outcomes in distinct RPL.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2025-09-19
DOI
https://doi.org/10.3389/fendo.2025.1644773
Primary Topic
Prenatal Screening and Diagnostics
Type
article
Field-Weighted Citation Impact
0.00

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article

Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status

Cuilian Zhang, Rui-Xiao Zhang, T. Luo, Chenchen Cui
Frontiers in Endocrinology
Prenatal Screening and Diagnostics
article

Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status

Cuilian Zhang, Rui-Xiao Zhang, T. Luo, Chenchen Cui
article en

Abstract

These findings suggest that the developmental stage of the blastocyst is the primary determinant of successful outcomes in BCT-associated RPL, whereas embryo morphological grading predominantly influences pregnancy outcomes in RPL patients with normal karyotypes. These results highlight the importance of personalized embryo selection strategies based on parental chromosomal status and embryological characteristics to optimize reproductive outcomes in distinct RPL.

Frontiers in EndocrinologyVol. 16
Zhengzhou University (CN), Henan Provincial People's Hospital (CN), Zhengzhou People's Hospital (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 64%
Prenatal Screening and Diagnostics
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Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status — Cuilian Zhang, Rui-Xiao Zhang, et al. · Frontiers in Endocrinology (2025) | TGRS Research Map | TGRS