DEFA5-producing CD4+ T cells in the intestines of atopic dermatitis patients play an important role in the development of AD-associated intestinal inflammation
AD is linked to an increase in intestinal DEFA5-expressing CD4<sup>+</sup> IELs, which may play an important role in mediating intestinal inflammation. This suggests that the DEFA5-expressing CD4<sup>+</sup> IELs could be a potential therapeutic target for managing gastrointestinal symptoms in AD patients.
Authors
- Sze Chun Leo Chan (ORCID: https://orcid.org/0000-0003-0674-8629)
- Yalan Wu (ORCID: https://orcid.org/0000-0002-1092-7542)
- Huanhuan Luo (ORCID: https://orcid.org/0000-0003-2298-3418)
- Kai Zhuang (ORCID: https://orcid.org/0000-0003-1724-6210)
- Ying Lin (ORCID: https://orcid.org/0000-0003-2473-7851)
- Yi Luo (ORCID: https://orcid.org/0000-0001-7051-219X)
- Jian Song (ORCID: https://orcid.org/0000-0002-1361-4410)
- Ziying Chen (ORCID: https://orcid.org/0009-0005-8931-6662)
- Yongliang Zhang (ORCID: https://orcid.org/0000-0002-8781-8504)
- Mengjun Li
- Jinmei Li (ORCID: https://orcid.org/0000-0002-4751-9307)
- Yanyan Ouyang (ORCID: https://orcid.org/0009-0006-6713-4996)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- National University of Singapore (SG)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1535527
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University