Absolute bioavailability and intravenous pharmacokinetics of N‐acetyl‐D‐mannosamine in humans
The low oral bioavailability of ManNAc is likely due to poor absorption (rather than first-pass hepatic extraction) due to its high polarity. In addition, zero-order absorption explains why the systemic exposure to ManNAc does not increase proportionally with dose.
Authors
- O. S. Pavlova (ORCID: https://orcid.org/0000-0002-2574-1978)
- Gianfranco Fornasini
- Guy Ludbrook (ORCID: https://orcid.org/0000-0001-6925-4277)
- Allan M. Evans (ORCID: https://orcid.org/0000-0001-5094-098X)
- Tahlia R. Meola (ORCID: https://orcid.org/0000-0002-7827-6256)
- Stephanie E. Reuter (ORCID: https://orcid.org/0000-0003-3888-7287)
- Sumit Kumar Jain
Institutions
- South Australia Pathology (AU)
- University of South Australia (AU)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1002/bcp.70292
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- University of South Australia