Roxadustat alleviates cisplatin-induced acute kidney injury by regulating fatty acid oxidation and mitochondrial function
We demonstrated that roxadustat exerts a protective role in cisplatin-treated mice and HK-2 cells, which might be due to amelioration of FAO deficiency and suppression of mitochondrial damage.
Authors
- Shougang Zhuang
- Xialin Li (ORCID: https://orcid.org/0000-0002-9955-5465)
- Daofang Jiang (ORCID: https://orcid.org/0000-0003-2461-419X)
- Yingfeng Shi
- Na Liu (ORCID: https://orcid.org/0000-0001-5806-8209)
- Shasha Zhang (ORCID: https://orcid.org/0000-0003-3431-7615)
- Qin Zhong
- Yan Hu
- Jinqing Li (ORCID: https://orcid.org/0000-0002-8954-392X)
- Xiaoyan Ma (ORCID: https://orcid.org/0009-0007-7953-947X)
Institutions
- Brown University (US)
- Rhode Island Hospital (US)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1080/0886022x.2025.2561218
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00