Comprehensive pan-cancer analysis reveals CGB5 is a potential promising predictive and immunotherapeutic biomarker
This study demonstrates that CGB5 expression is closely associated with immune cell infiltration across cancer types, showing significant variation in infiltration patterns among tumor types. CGB5 is significantly up-regulated in various malignancies and strongly correlates with cancer patient prognoses, specifically in malignancies like GC and PAAD. Overall, these findings indicate CGB5 as a promising biomarker for pan-cancer diagnosis and prognosis.
Authors
- Shan Lin (ORCID: https://orcid.org/0000-0001-5163-6533)
- Weifeng Yu (ORCID: https://orcid.org/0000-0003-1979-6304)
- Guiping Ma (ORCID: https://orcid.org/0000-0002-4800-2414)
- Feng Li (ORCID: https://orcid.org/0000-0003-3636-2962)
- Haibin He (ORCID: https://orcid.org/0000-0002-1225-0272)
- Yuanjie Zhang (ORCID: https://orcid.org/0000-0003-0101-9670)
- Shuni Chen
Institutions
- Beijing University of Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fmed.2025.1624815
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00