A two-transcript classifier model of host genes for discrimination of bacterial from viral infection in ulcerative colitis with opportunistic infections: a discovery and validation study
<i>IFI44L</i> and <i>PI3</i> transcript levels are robust classifiers to discriminate bacterial from viral infection in UC-OI, and measuring its levels appears to be predictive infection progression and treatment outcome in UC patients over time.
Authors
- Yanbo Yu (ORCID: https://orcid.org/0000-0003-2995-3270)
- Gang Wang (ORCID: https://orcid.org/0000-0001-7264-2457)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-3082-8330)
- Gang Huang (ORCID: https://orcid.org/0009-0008-3315-0634)
- Manyu Li (ORCID: https://orcid.org/0000-0002-8679-1346)
- Huipeng Zhang (ORCID: https://orcid.org/0009-0002-5328-2489)
- Nan-Nan Xu
- Guorong Bi
- Ahemala Duishanbai
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1642923
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China