Dysregulated NK cell activation and myeloid-lymphoid imbalance underpin COPD progression: insights from high-dimensional immune profiling and smoking-induced immune remodeling
This study underscores the value of peripheral immune profiling in capturing the heterogeneity of COPD. The results reveal systemic immune dysregulation-especially NK cell hyperactivity and point to potential therapeutic avenues aimed at modulating immune responses to slow disease progression.
Authors
- Hongtao Niu (ORCID: https://orcid.org/0000-0002-6455-3224)
- Ke Huang (ORCID: https://orcid.org/0000-0003-3546-9776)
- Ting Yang (ORCID: https://orcid.org/0000-0002-7027-5179)
- Shiwei Qumu (ORCID: https://orcid.org/0000-0003-3477-4429)
- Ling Ni (ORCID: https://orcid.org/0000-0003-1569-882X)
- Qin Qiao (ORCID: https://orcid.org/0000-0003-2085-6853)
- Xiaoxia Ren (ORCID: https://orcid.org/0000-0003-4079-2789)
- Wei Li (ORCID: https://orcid.org/0000-0001-9003-3508)
- Chen Dong (ORCID: https://orcid.org/0000-0002-0084-9130)
- Yazheng Yang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Westlake University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1623319
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Key Research and Development Program of China