Monosodium urate crystals exposure is associated with limited transcriptional changes in primary human PBMCs
We confirm the synergistic effect of MSU crystals with palmitate that leads to higher IL-1β production. Transcriptomic analysis shows that MSU crystal exposure is not associated with major transcriptional changes in PBMCs. This suggests that the production of IL-1β in response to MSU crystals may largely be regulated at the post-transcriptional level and additional synergistic stimuli are likely required to fully explain the inflammatory response observed clinically in gout. Moreover, this could also bear relevance for other metabolic disorders associated to hyperuricemia where asymptomatic MSU crystal deposition may be present.
Authors
- Orsolya I. Gaal (ORCID: https://orcid.org/0000-0002-4726-915X)
- Tania O. Crișan (ORCID: https://orcid.org/0000-0002-3282-5627)
- Valentin Nica (ORCID: https://orcid.org/0009-0005-3269-3985)
- Cristina Pamfil (ORCID: https://orcid.org/0000-0003-0175-2645)
- Leo A. B. Joosten (ORCID: https://orcid.org/0000-0001-6166-9830)
- Simona Rednic (ORCID: https://orcid.org/0000-0001-8149-7722)
- Maartje C. P. Cleophas
- Tim Jansen (ORCID: https://orcid.org/0000-0003-3026-3154)
- Georgiana Cabău (ORCID: https://orcid.org/0000-0001-8914-2352)
- Akshayata Naidu (ORCID: https://orcid.org/0000-0001-8958-2622)
- Radu A. Popp (ORCID: https://orcid.org/0000-0002-1494-5369)
- Medeea Badii (ORCID: https://orcid.org/0000-0002-1185-8729)
- Ioana Hotea (ORCID: https://orcid.org/0000-0003-2552-9835)
- Li Yang (ORCID: https://orcid.org/0000-0002-9337-1382)
Institutions
- Radboud University Nijmegen (NL)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Radboud University Medical Center (NL)
- VieCuri Medisch Centrum (NL)
- Centre for Individualised Infection Medicine (DE)
Publication Details
- Journal
- Romanian Journal of Internal Medicine
- Published
- 2025-09-18
- DOI
- https://doi.org/10.2478/rjim-2025-0019
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00