Obesity‐Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility
These findings underscore a pathogenic form of vascular-adipose crosstalk in obesity, where adiposome-mediated signaling alters VSMC excitability and vascular tone. Targeting this inter-organ communication axis may offer new strategies to reverse obesity-related vascular complications.
Authors
- Francesco M. Bianco (ORCID: https://orcid.org/0000-0002-6778-3842)
- Abeer M. Mahmoud (ORCID: https://orcid.org/0000-0002-0295-6706)
- Mohammed Morsy (ORCID: https://orcid.org/0000-0003-2057-9382)
- Brian Thomas Layden (ORCID: https://orcid.org/0000-0003-2176-5654)
- Imaduddin Mirza
- Sarah M. Mostafa
- J. Usha Raj (ORCID: https://orcid.org/0000-0002-7095-6820)
- Mario A. Masrur (ORCID: https://orcid.org/0000-0003-0660-801X)
- Paola C. Rosas (ORCID: https://orcid.org/0000-0002-8131-310X)
- Chandra Hassan (ORCID: https://orcid.org/0000-0002-0219-6735)
- Irena Levitan
- Elsayed Metwally
Institutions
- Suez Canal University (EG)
- Illinois College (US)
- Chicago Department of Public Health (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Jesse Brown VA Medical Center (US)
Publication Details
- Journal
- Comprehensive physiology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1002/cph4.70053
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00