Silica-Based Fiber Universal Combat Matrix Reduces Inflammation, Supporting Cellular Migration and Extracellular Matrix Remodeling in Porcine Full-Thickness Burns
Silica-based fiber treatment improved epidermal rete ridge formation, enhanced ECM collagen remodeling, and reduced inflammatory cell infiltration while maintaining normal cellular proliferation. These findings indicate that SBF not only minimizes inflammation compared to standard gauze treatment but also provides an optimal scaffold environment for tissue regeneration. Given its unique mechanism of action, ultralight weight, stability under ambient conditions, and user-friendly design, SBF shows strong potential for military and civilian applications, particularly in austere prehospital care and mass casualty scenarios.
Authors
- Justin S. Campbell (ORCID: https://orcid.org/0000-0002-3471-9430)
- Adam Jorgensen (ORCID: https://orcid.org/0000-0002-5199-9294)
- Lysette Mutkus (ORCID: https://orcid.org/0000-0002-7378-7137)
- William L. Hickerson (ORCID: https://orcid.org/0009-0009-1817-4002)
- Ronald A Nelson
- Anthony Atala (ORCID: https://orcid.org/0000-0001-8186-2160)
- Sean V. Murphy (ORCID: https://orcid.org/0000-0002-2820-2451)
- Kristina Stumpf (ORCID: https://orcid.org/0000-0002-3422-5959)
- Cara Clouse (ORCID: https://orcid.org/0009-0005-9892-8337)
- Frank C. Marini (ORCID: https://orcid.org/0000-0001-8190-6186)
- Darren Hickerson
- Thomas Shupe
Institutions
- Regenmedtx (United States) (US)
- Wake Forest University (US)
Publication Details
- Journal
- Military Medicine
- Published
- 2025-05-21
- DOI
- https://doi.org/10.1093/milmed/usaf256
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00