Impaired coronary flow reserve by hyperviscosity in a mouse model of non-light chain multiple myeloma: a mechanism of coronary flow impairment at the capillary level
Our study shows a potentially completely new mechanism of cardiovascular adverse effects caused by MM or more broadly by hyperviscosity syndromes, i.e. CFR impairment at the capillary level. Since capillaries, unlike larger vessels, cannot be recanalized or dilated, completely new preventive approaches are needed, such as agents affecting blood rheology.
Authors
- Aleksandra Paterek (ORCID: https://orcid.org/0000-0002-6131-6004)
- Michał Ma̧czewski (ORCID: https://orcid.org/0000-0002-3157-4141)
- Tomasz Skirecki (ORCID: https://orcid.org/0000-0001-6233-7758)
- Zofia Pilch (ORCID: https://orcid.org/0000-0002-8214-7158)
- Grażyna Hoser (ORCID: https://orcid.org/0000-0002-0917-5611)
- Filip Rolski (ORCID: https://orcid.org/0000-0001-9159-6169)
- Jakub Gołąb (ORCID: https://orcid.org/0000-0002-2830-5100)
- Karol Czubak (ORCID: https://orcid.org/0000-0002-0489-8773)
- Dominika Nowis (ORCID: https://orcid.org/0000-0003-2748-9523)
- Mateusz Surzykiewicz (ORCID: https://orcid.org/0009-0001-1015-6776)
Institutions
- Medical University of Warsaw (PL)
- Postgraduate School of Molecular Medicine (PL)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-15
- DOI
- https://doi.org/10.1093/cvr/cvaf164
- Citations
- 1
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.39