Buyang Huanwu Decoction enhances hippocampal-cortical connectivity remodeling via sonic hedgehog signaling to ameliorate memory dysfunction in cerebral ischemic rats
The treatment with BHD facilitated the remodeling of the connectivity between the hippocampus and cortex, and ultimately alleviated memory dysfunction following stroke. These findings hold great promise in promoting the development of BHD research and enhancing its clinical utility.
Authors
- Jianping Jia (ORCID: https://orcid.org/0000-0003-4624-0336)
- Binbin Nie (ORCID: https://orcid.org/0000-0002-8038-7772)
- Yun Lu (ORCID: https://orcid.org/0009-0002-4279-717X)
- Yuxuan Wang (ORCID: https://orcid.org/0000-0001-9981-0588)
- Haiyan Zou (ORCID: https://orcid.org/0000-0002-3760-4831)
- Mingcong Li (ORCID: https://orcid.org/0000-0002-5687-8870)
- Yuming Zhuang
- Ziyue Lin
- Jianfeng Lei
- Man-zhong Li (ORCID: https://orcid.org/0009-0007-5040-9444)
- Pan Xu (ORCID: https://orcid.org/0000-0001-9324-1513)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-2968-0682)
- Hanyu Wang (ORCID: https://orcid.org/0000-0002-6923-680X)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-1327-2577)
- Le Yang
Institutions
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Institute of High Energy Physics (CN)
- Beijing YouAn Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1186/s13020-025-01122-0
- Citations
- 2
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Natural Science Foundation of China