Research on the Synthetic Methodology for Lurasidone Hydrochloride

Abstract In this study, the antipsychotic drug ruprasidone hydrochloride was synthesized using (1R,2R)-1,2-cyclohexanedimethanol as the starting material. The synthesis process was carried out through four steps: sulfonylation, N-alkylation, substitution, and acidification with hydrochloric acid. Eventually, lurasidone hydrochloride was obtained with a total yield of 34.3%, calculated based on (1R,2R)-1,2-cyclohexanedimethanol. The structure of the target compound was confirmed by 1H NMR and 13C NMR spectroscopic analyses. The reported synthetic process offers several advantages of high yield, simple steps, high cost-effectiveness and safe operation, and the synthetic process is suitable for industrial production. This study provides a methodological reference for the industrial manufacturing of ruprasidone hydrochloride.