Heterobenzylic C(sp3)─H Acylation of Isoindolinones via Photoinduced Intermolecular Hydrogen Atom Transfer Strategy
Abstract Heterobenzylic C(sp3)−H functionalization of isoindolinones remains challenging yet highly desirable. Herein, we present a photo-induced hydrogen atom transfer (HAT) strategy for heterobenzylic C(sp3)−H acylation of isoindolinones using acyl azolium salts under mild reaction conditions. This metal-free protocol offers excellent functional group compatibility and avoids the usage of Lewis acids or oxidants, providing a sustainable and efficient approach to C–H acylation.
Authors
- C Sivaraj (ORCID: https://orcid.org/0000-0001-9170-0827)
- Thirumanavelan Gandhi (ORCID: https://orcid.org/0000-0002-0461-5155)
- Karthick Muthuvel (ORCID: https://orcid.org/0000-0003-1057-0560)
Institutions
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- Synlett
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1055/a-2705-8764
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00