Mood Stabilizers (Lamotrigine, Lithium, and Valproic Acid) Decrease Bipolar Disease Model (Ouabain)‐Induced Oxidative Stress and Apoptosis Through the Inhibition of the TRPM2 Channel in Neuronal Cells
The treatments of Li, VPA, and LMT modulate OUA-mediated mROS, apoptosis, Zn<sup>2+</sup>, glutathione, and TRPM2-mediated excess Ca<sup>2+</sup> influx. This could potentially offer protection against BD linked to elevated levels of mROS, Ca<sup>2+</sup>, and Zn<sup>2+</sup>.
Authors
- Mustafa Nazıroğlu (ORCID: https://orcid.org/0000-0003-0887-6974)
- İ̇brahim Eren (ORCID: https://orcid.org/0000-0003-1626-7810)
- E L Kaplan (ORCID: https://orcid.org/0000-0001-7806-9532)
Institutions
- Süleyman Demirel Üniversitesi (TR)
- Suleyman Demirel University (KZ)
- Drug Discovery Laboratory (Norway) (NO)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/bdi.70053
- Primary Topic
- Aluminum toxicity and tolerance in plants and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00