Increased Prevalence of an Oxytocin Receptor Gene Variant in Functional Neurological Disorder: A Case-Control Study
These preliminary results suggest that genetic factors in the oxytocinergic system and sex-specific structural changes in the insula and amygdala contribute to vulnerability to FND. Because oxytocin is a regulatory factor in stress responses, decreased activity of some FND-associated <i>OXTR</i> gene variants might affect stress responses and regulation in FND in a sex-dependent manner.
Authors
- Raquel Cruz
- Janine Bühler (ORCID: https://orcid.org/0000-0003-0318-8371)
- Juan Ansede‐Bermejo (ORCID: https://orcid.org/0000-0002-0576-6131)
- Samantha Weber (ORCID: https://orcid.org/0000-0002-2689-2938)
- Selma Aybek (ORCID: https://orcid.org/0000-0002-7877-6760)
- Ãngel Carracedo (ORCID: https://orcid.org/0000-0003-1085-8986)
- Lucía Trinidad Rey Álvarez
- Natascha Stoffel (ORCID: https://orcid.org/0009-0000-4198-4921)
- Álvaro Del Real Bolt
Institutions
- Australian National University (AU)
- University of Bern (CH)
- Universidad de Cantabria (ES)
- University of Fribourg (CH)
- Universidade de Santiago de Compostela (ES)
- University Hospital of Bern (CH)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
Publication Details
- Journal
- Journal of Neuropsychiatry
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1176/appi.neuropsych.20250031
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00