Sex-stratified and ascorbic acid intake-modified associations between body roundness index and biological aging: a NHANES-based study on interactions and mediation
A higher BRI showed a nonlinear positive association with accelerated biological aging, a relationship that appears to be modified by female sex and Asc intake. Clinical approaches targeting metabolic dysfunction, oxidative stress, and antioxidant and vasoprotective reserves may help combat obesity-related aging. BRI thresholds enable early identification of individuals at high risk for personalized interventions.
Authors
- Xing Qu (ORCID: https://orcid.org/0000-0002-7696-7192)
- Guosong Jiang (ORCID: https://orcid.org/0009-0009-2367-4079)
- Xinxing Wang (ORCID: https://orcid.org/0000-0002-1581-4846)
Institutions
- Kunming Medical University (CN)
- Wenzhou Medical University (CN)
- Zhaotong University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1186/s12944-025-02708-1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian Medical University
- Chinese People’s Liberation Army