Direct palladium-catalyzed C–H arylation of bioactive triazolyl- <i>C</i> -nucleosides on a key position of the heterocyclic base
Regarding the potential of nucleosides in therapeutics, especially as antiviral and anticancer drugs, the expansion of the chemical space of such molecules appears urgent. Herein, a direct palladium-catalyzed C-H arylation of the triazolyl pseudonucleobase of bioactive <i>C</i>-nucleosides is described with 14 examples bearing different aryl moieties and decorations on the nucleoside core.
Authors
- Bartosz Godlewski (ORCID: https://orcid.org/0000-0003-0673-1480)
- Nina Božinović (ORCID: https://orcid.org/0000-0002-6476-2202)
- Nadège Lubin-Germain
- Olivier Monasson (ORCID: https://orcid.org/0000-0002-0886-1687)
- Angélique Ferry (ORCID: https://orcid.org/0000-0001-9141-5479)
- Quentin Joachim
Institutions
- Warsaw University of Technology (PL)
- Centre National de la Recherche Scientifique (FR)
- Institut Universitaire de France (FR)
- Université Paris-Saclay (FR)
- Centre de Recherche des Cordeliers (FR)
- Laboratoire de Chimie (FR)
- CY Cergy Paris Université (FR)
- Laboratoire des Biomolécules (FR)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04215a
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00