MIF Facilitates Resistance to Androgen Deprivation Therapy by Regulating AMPD2 Expression in Prostate Cancer Cells
Our findings demonstrate that ADT induces MIF upregulation, which in turn drives prostate cancer cell proliferation via upregulating AMPD2 expression, eventually contributing to the development of resistance to ADT.
Authors
- Kuo Yang (ORCID: https://orcid.org/0000-0001-6192-8804)
- Yuhong Feng (ORCID: https://orcid.org/0000-0002-6138-5229)
- Changying Li
- Jiancheng Pan (ORCID: https://orcid.org/0000-0002-7703-7667)
- Jinhuan Meng
- Changlin Li (ORCID: https://orcid.org/0000-0001-5872-6443)
- Dawei Tian (ORCID: https://orcid.org/0000-0003-1428-4422)
- Chenchen He (ORCID: https://orcid.org/0000-0001-9082-2611)
- Zhi Qi (ORCID: https://orcid.org/0000-0002-7819-4736)
Institutions
- Tianjin University (CN)
- Nankai University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The Prostate
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1002/pros.70053
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00