Loss of Beclin 1 primes colorectal cancer cells for Immunogenic necroptosis via transcriptional de-repression of RIPK1/RIPK3/MLKL axis

These findings Suggest that Beclin 1 maintains cellular Survival not solely through autophagy but also by repressing necroptosis at the transcriptional level. Its loss reconfigures CRC cell fate, predisposing them to inflammatory, caspase-independent death. Targeting Beclin 1 may therefore expose a previously unrecognised vulnerability in apoptosis-resistant CRC, opening new avenues for necroptosis-based immunotherapeutic interventions.