Extracellular vesicles from prostate tumors reshape the pre-metastatic bone environment in an mTOR/RAB1A-dependent manner
Our findings elucidated the detailed mechanism by which mTOR/RAB1A regulates EV secretion, providing new insight into cellular changes involved in PMN formation and a theoretical basis for the inhibition of the PMN in the development of targeted therapies for PCa. RAB1A represents a therapeutic target to reverse tEV-mediated immunosuppression, while peripheral B-cell dynamics provide diagnostic biomarkers for early metastasis detection.
Authors
- Xiaojin Guo (ORCID: https://orcid.org/0000-0003-2370-8557)
- Chunwang Yang
- Yuehua Zhang (ORCID: https://orcid.org/0000-0003-1432-5423)
- Xiaokuan Zhang (ORCID: https://orcid.org/0000-0002-4646-7146)
- Dongwei He (ORCID: https://orcid.org/0000-0003-2212-1973)
- Zhiyu Wang (ORCID: https://orcid.org/0000-0002-5299-8410)
- Xing Li (ORCID: https://orcid.org/0000-0001-9145-4769)
- Yawen Guo (ORCID: https://orcid.org/0000-0002-9575-4192)
- Jing Cao (ORCID: https://orcid.org/0009-0000-2161-8385)
- Tingting Lv
- Dehua Wang (ORCID: https://orcid.org/0000-0001-5626-736X)
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1605494
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00