Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study
Exposure to organophosphate esters (OPEs) is associated with the development of geriatric diseases. However, the impact of OPEs on oxidative stress, a precursor of geriatric diseases, remains unclear in older adults. Based on the China BAPE study, a panel study with multiple repeated measurements, we collected urine samples from 76 healthy older adults to measure OPEs and oxidative stress markers, aiming to investigate both individual and combined OPE exposures in relation to oxidative stress. Our results indicated that Dibutyl phosphate (DBP), Bis-(2-ethylhexyl) phosphate (BEHP), Bis-(1,3-dichloro-2-propyl) phosphate (BDCIPP), Diphenyl phosphate (DPHP), and Bis-(2-methylphenyl) phosphate (BMPP) exposure were significantly associated with increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), and malondialdehyde (MDA). Household heating status had a modifying effect on these associations. Generalized additive mixed models revealed potential linear and nonlinear associations between OPEs and oxidative stress markers. The quantile g-computation and Bayesian kernel machine regression further found positive effects of OPEs mixtures on 8-OHdG, 8-OHG, and MDA. Weighted distribution analyses identified BEHP as a potentially contributing component affecting oxidative stress. These findings not only illuminate the health hazards of OPE exposures but also aid in understanding the link between OPEs and adverse health outcomes in older adults.
Authors
- Minmin Hou (ORCID: https://orcid.org/0000-0002-2570-9468)
- Enmin Ding (ORCID: https://orcid.org/0000-0002-3805-1386)
- Jianlong Fang (ORCID: https://orcid.org/0000-0003-4716-390X)
- Peijie Sun (ORCID: https://orcid.org/0000-0003-1504-5634)
- Chenlong Li (ORCID: https://orcid.org/0000-0002-5463-4661)
- Xiaoming Shi (ORCID: https://orcid.org/0000-0002-7071-571X)
- Tong Shen (ORCID: https://orcid.org/0000-0003-1299-106X)
- Ximiao Zhao
- Song Tang (ORCID: https://orcid.org/0000-0003-3219-1422)
- Yaqi Cai (ORCID: https://orcid.org/0000-0002-2805-5535)
- Xiaojie Guo (ORCID: https://orcid.org/0000-0002-6800-2569)
- Yali Shi (ORCID: https://orcid.org/0000-0001-9946-1525)
- Chenfeng Li (ORCID: https://orcid.org/0000-0003-0441-211X)
- Kangning Cao
- Yu Wang (ORCID: https://orcid.org/0000-0002-9480-3570)
- Shilu Tong (ORCID: https://orcid.org/0000-0001-9579-6889)
- Keke Long (ORCID: https://orcid.org/0000-0002-6887-6135)
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-8375-2982)
- Jiankun Qian
- Yibo Xu
- Yifu Lu (ORCID: https://orcid.org/0000-0002-2563-8030)
- Huimin Ren
- Fuchang Deng
Institutions
- Shandong University (CN)
- Queensland University of Technology (AU)
- Chinese Center For Disease Control and Prevention (CN)
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Taiwan Centers for Disease Control (TW)
- Research Center for Eco-Environmental Sciences (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Institute for Forecasting of the Slovak Academy of Sciences (SK)
- National Institute for Occupational Health and Poison Control (CN)
- State Key Laboratory of Environmental Chemistry and Ecotoxicology
- Southern Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Environment & Health
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1021/envhealth.5c00050
- Citations
- 1
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.20