Therapeutic Effect of LEV in a Propionic Acid‐Induced Autism Model via AMPK/SIRT1 Pathway
LEV treatment ameliorated PPA-induced behavioural, biochemical and histological impairments, likely via anti-inflammatory, antioxidant and neuroprotective mechanisms involving activation of the AMPK/SIRT1 pathway. These findings support LEV as a potential therapeutic candidate for autism spectrum disorder.
Authors
- Oytun Erbaş (ORCID: https://orcid.org/0000-0001-5427-8428)
- Yiğit Uyanıkgil (ORCID: https://orcid.org/0000-0002-4016-0522)
- İlknur Altuntaş (ORCID: https://orcid.org/0000-0003-4402-754X)
- Mümin Alper Erdoğan (ORCID: https://orcid.org/0000-0003-0048-444X)
- Tarık Mecit
Institutions
- Gebze Technical University (TR)
- Izmir Kâtip Çelebi University (TR)
- Ege University (TR)
- Biruni University (TR)
Publication Details
- Journal
- International Journal of Developmental Neuroscience
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/jdn.70055
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00