Role of A <sub>2A</sub> R-D2R Dimerization and D <sub>2</sub> R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy
Our findings reveal A<sub>2A</sub>R-D<sub>2</sub>R dimerization and βarr2-biased D<sub>2</sub>R signaling as novel and critical mechanisms for counteracting pathological CM hypertrophy and cardiac dysfunction. PDE10A acts as a pivotal negative regulator of this signaling axis. Targeting PDE10A, A<sub>2A</sub>R-D<sub>2</sub>R/βarr2 signaling, or both offers potentially novel therapeutic strategies for combating pathological cardiac remodeling and cardiac dysfunction.
Authors
- Hangchuan Shi (ORCID: https://orcid.org/0000-0001-6269-742X)
- Sumin Xu (ORCID: https://orcid.org/0000-0002-4956-2501)
- Yan Chen (ORCID: https://orcid.org/0000-0002-1397-6358)
- Ningwen Zhu (ORCID: https://orcid.org/0000-0003-4224-4188)
- Zheng-gen Jin
- Si Chen (ORCID: https://orcid.org/0000-0002-3228-2837)
- Xinyue Fan (ORCID: https://orcid.org/0000-0002-0328-7284)
Institutions
- University of Rochester (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1161/circulationaha.125.075465
- Citations
- 3
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.42