Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart
TGF-β signaling plays a central role in maintaining fibroblast cell specification after cardiac injury. Fibroblast-to-adipocyte conversion induced by disrupted TGF-β signaling may underlie scar-associated lipomatous metaplasia and may play an important role in the pathogenesis of heart failure and arrhythmogenesis in patients with ischemic cardiomyopathy.
Authors
- Harikrishnan Venugopal (ORCID: https://orcid.org/0000-0002-1277-3612)
- Izabela Tuleta (ORCID: https://orcid.org/0000-0002-8482-591X)
- Deyou Zheng (ORCID: https://orcid.org/0000-0003-4354-5337)
- Nikolaos Georgios Frangogiannis (ORCID: https://orcid.org/0000-0002-8186-5131)
- Kevin O’Leary (ORCID: https://orcid.org/0000-0001-7120-0550)
Institutions
- Albert Einstein College of Medicine (US)
- Voluntary Health Association Of India (IN)
Publication Details
- Journal
- Circulation
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1161/circulationaha.125.075676
- Citations
- 3
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 4.16