Neovascular Age-Related Macular Degeneration Treated with Aflibercept: Five-Year Follow-Up and Correlation with Optical Coherence Tomography Biomarkers in a Real-World Setting
Baseline SHRM in type 2 MNV may predict more IRF, ORT, and RPE tears over time. Type 1 MNV with baseline SRF often shows reduced HS and dPED but may develop subretinal fibrosis. BCVA gains after loading wane by year 5, and eyes needing ongoing treatment for persistent OCT biomarkers decline gradually in both subtypes (significant in type 1).
Authors
- Vincenzo Mollace (ORCID: https://orcid.org/0000-0002-0392-7173)
- Teresa Angela Trunfio (ORCID: https://orcid.org/0000-0003-0929-567X)
- Vincenzo Scorcia (ORCID: https://orcid.org/0000-0001-6826-7957)
- Sandrine Zweifel (ORCID: https://orcid.org/0000-0001-7431-1774)
- Adriano Carnevali (ORCID: https://orcid.org/0000-0002-9950-6743)
- Giovanni Improta (ORCID: https://orcid.org/0000-0002-9485-1687)
- Massimiliano Borselli (ORCID: https://orcid.org/0000-0001-5262-9765)
- Mario Damiano Toro (ORCID: https://orcid.org/0000-0001-7152-2613)
- Arianna Scala (ORCID: https://orcid.org/0000-0001-9735-5227)
- Mutasem Elfalah (ORCID: https://orcid.org/0000-0002-9677-6203)
- Andrea Lucisano (ORCID: https://orcid.org/0000-0003-1382-0828)
- Giovanna Carnovale-Scalzo
- Alessandra Mancini (ORCID: https://orcid.org/0000-0001-7719-5772)
- Domenico Chisari
Institutions
- University of Jordan (JO)
- University of Zurich (CH)
- Magna Graecia University (IT)
- University Hospital of Zurich (CH)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Ophthalmology and Therapy
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1007/s40123-025-01232-w
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00