Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial

The adjunctive use of injectable platelet-rich fibrin (i‑PRF) after surgical removal of impacted mandibular third molars may contribute to improve early postoperative outcomes by attenuating soft tissue inflammation, reducing pain intensity, and accelerating wound healing. By potentially lowering the need for nonsteroidal anti-inflammatory drugs (NSAIDs) and minimizing associated adverse effects, i‑PRF represents a minimally invasive, autologous approach that could enhance patient comfort, reduce recovery time, and support faster return to daily activities.