Sitagliptin ameliorates microbial dysbiosis and enhances gut barrier integrity in streptozotocin-induced type 2 diabetic rats
Sitagliptin effectively ameliorates gut microbial dysbiosis and restores intestinal barrier function in STZ-induced T2DM rats. These findings provide novel insights into the gut-related therapeutic effects of sitagliptin and underscore its potential in restoring gut homeostasis in T2DM.
Authors
- Jie Liang (ORCID: https://orcid.org/0000-0002-6792-8941)
- Yuanjiang Zhou
- Mingyuan Tian (ORCID: https://orcid.org/0000-0002-4645-3625)
- Fanlin Zhou
- Yu Li (ORCID: https://orcid.org/0000-0003-3056-2680)
- Ying Chang (ORCID: https://orcid.org/0009-0008-9146-8122)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Cancer Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fmicb.2025.1655522
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chongqing Science and Technology Commission
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment