Syphilis in pregnancy: Risk factors and maternal-fetal prognosis in Kisangani

<ns3:p>Background Syphilis is a cosmopolitan infection, with recent infections (primary or secondary syphilis &lt;1 year) posing the highest risk of mother-to-child transmission. In such cases, early treatment is crucial in determining obstetric prognosis. Objective This study aims to present current data of syphilis in pregnant women and improve the management of syphilis in pregnant women in the city of Kisangani. Methods This is an analytical case-control study covering the period from July 1, 2023, to December 1, 2023. The study was conducted at Makiso Kisangani General Referral Hospital, with a study population of 290 pregnant women. A non-exhaustive sampling method was used, selecting, in the obstetrical department, a sample of 145 pregnant women diagnosed with syphilis and 145 others diagnosed with out syphilis. Data were analyzed using R software version 4.3. Results The most represented age group was 20 to 34 years (61.4%). The majority of pregnant women with syphilis were married (61.4%), in monogamous relationships (72.4%), and had unemployed partners (26.9%). The most common risk factors were having a partner who was a driver (OR: 3.31; p = 0.028), a trader (OR: 8.08; p &lt;0.001), and having a history of STIs (p &lt;0.001) or multiple sexual partners (p = 0.011). In 75% of cases, pregnancy resulted in the birth of a live fetus and 25% cases result in the birth of a died fetus. Conclusion Adverse pregnancy outcomes associated with syphilis could be reduced through early detection and standard treatment of syphilis for pregnant women and their husbands/sexual partners.</ns3:p>