Machine Learning Identifies Shared Regulatory Mechanisms of Genes Associated with Ferroptosis in Major Depressive Disorder and Inflammatory Bowel Disease
These discoveries enhance the understanding of the shared and distinct regulatory mechanisms of FRGs in gut-brain axis disorders. We have pinpointed key biomarkers and predicted potential therapeutic agents that may offer dual-targeting strategies for both IBD and MDD.
Authors
- Mengmeng Sang (ORCID: https://orcid.org/0000-0001-5249-002X)
- Lingxi Li (ORCID: https://orcid.org/0000-0002-9471-9774)
- Liucheng Wu (ORCID: https://orcid.org/0000-0002-8053-1340)
- Yuxuan Lu (ORCID: https://orcid.org/0009-0003-8718-9159)
- Liming Mao (ORCID: https://orcid.org/0000-0002-9740-820X)
- Ye Liu (ORCID: https://orcid.org/0000-0002-4955-9273)
- Jiyuan Shi
Institutions
- Nantong University (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3390/genes16091111
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00