Lack of immunogenicity for an influenza‐derived peptide across the HLA‐B44 supertype molecules

Although HLA molecules from the same supertype may be able to present the same peptide, this will not always result in CD8⁺ T-cell responses. As such, HLA-I supertypes, defined based on peptide binding motif and presentation, do not include information on immunogenicity and are not currently able to be used on their own to select epitopes as vaccine candidates. However, new knowledge on HLA supertypes may help curate sets of peptides that are potential vaccine targets and applicable to a range of HLA allomorphs.