Increased methylation levels of the <i>MTHFR</i> gene promoter in Down syndrome
We observed a significant increase in <i>MTHFR</i> promoter methylation levels in DS individuals compared to controls. Folate metabolism could influence <i>MTHFR</i> methylation levels as shown indirectly by the association of the <i>MTHFR 677C > T</i> polymorphism.
Authors
- Jadranka Vraneković (ORCID: https://orcid.org/0000-0001-6365-5686)
- Alena Buretić‐Tomljanović (ORCID: https://orcid.org/0000-0002-9840-1245)
- Anita Barišić (ORCID: https://orcid.org/0000-0002-5403-3129)
- Fabio Coppedè (ORCID: https://orcid.org/0000-0002-3081-6647)
- Andrea Stoccoro (ORCID: https://orcid.org/0000-0002-6768-8466)
- Vanessa Nicolì (ORCID: https://orcid.org/0000-0003-2751-7352)
- Dijana Majstorović (ORCID: https://orcid.org/0000-0002-2933-7497)
- Martin Giangreco
Institutions
- University of Pisa (IT)
- University of Rijeka (HR)
- Juraj Dobrila University of Pula (HR)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1080/17501911.2025.2563501
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00