Kaixin San Jiawei granule improves cognitive function and alleviates neuronal damage in Alzheimer’s disease via multi-component and multi-target mechanisms
KSG improves cognitive function and attenuates Aβ-induced neuronal damage in AD through multi-component, multi-target synergistic mechanisms. These effects appear to be mediated by modulation of the cholinergic system, inhibition of oxidative stress and inflammation, and suppression of neuronal apoptosis. These findings provide a theoretical basis and experimental support for developing novel AD therapies based on traditional Chinese medicine.
Authors
- Yanan Zhao
- Tingting Liu (ORCID: https://orcid.org/0000-0003-2314-9898)
- Yahan Wang
- Shengcan Zou
- Hongwei Zhi
- Wei Liu (ORCID: https://orcid.org/0000-0003-1729-6760)
- Changqing Zou (ORCID: https://orcid.org/0000-0001-8264-6849)
- Dexin Yin (ORCID: https://orcid.org/0000-0003-3216-5136)
- Yilei Wang (ORCID: https://orcid.org/0009-0000-2743-4595)
- Zezheng Zhang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- University of California, Irvine (US)
- Qingdao Center of Resource Chemistry and New Materials (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.3389/fphar.2025.1650534
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00