Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation
Features of ARIA-E (parenchymal white matter hyperintensities, sulcal hyperintensities, and gyral swelling) are more common in CAA-ri in comparison with "non-inflammatory" sporadic CAA, suggesting shared mechanisms with Alzheimer's disease immunotherapy and a potential role in improving diagnostic accuracy for CAA-ri. The high prevalence of atrophy and lobar cerebral microbleeds suggests a potential mechanistic role for capillary CAA, Alzheimer's disease, or both, in CAA-ri. Cardiovascular risk factors and other long-term comorbidities may also be relevant to the underlying mechanisms of CAA-ri. ANN NEUROL 2026;99:148-158.
Authors
- Gargi Banerjee (ORCID: https://orcid.org/0000-0003-0190-7782)
- Rupert Oliver
- Dermot Mallon (ORCID: https://orcid.org/0000-0001-7434-1201)
- Michael S. Zandi (ORCID: https://orcid.org/0000-0002-9612-9401)
- Victoria L. Harvey (ORCID: https://orcid.org/0000-0001-5956-6664)
- Kitti Thiankhaw (ORCID: https://orcid.org/0000-0002-0556-541X)
- Hans Rolf Jäger (ORCID: https://orcid.org/0000-0002-6403-4184)
- Gareth Ambler (ORCID: https://orcid.org/0000-0002-5322-7327)
- Larysa Panteleienko (ORCID: https://orcid.org/0000-0002-7342-2488)
- David John Werring (ORCID: https://orcid.org/0000-0003-2074-1861)
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Queen Mary University of London (GB)
- Stroke Association (GB)
- MRC Prion Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Chiang Mai University (TH)
- Bogomolets National Medical University (UA)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1002/ana.78029
- Citations
- 2
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78