Therapeutic Potential of Cepharanthine in Ovarian Ischemia-Reperfusion Injury: Insights from a Rat Ovarian Torsion-Detorsion Model
This study evaluated the potential protective effects of Cepharanthine (CEP) in mitigating ischemia-reperfusion (I/R) injury of an ovarian torsion/detorsion (T/D) rat model. Twenty-four female Sprague-Dawley rats were randomized into three experimental groups: sham, T/D, and CEP 10 mg/kg. The study examined ovarian tissue samples to measure oxidative stress biomarkers, such as malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD), as well as proinflammatory mediators, specifically tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). The T/D group exhibited significant oxidative stress, characterized by elevated MDA and MPO levels and low SOD activity, along with heightened inflammatory responses, as indicated by elevated TNF-α and IL-1β levels (p
Authors
- Fazile Nur Eki̇nci̇ Akdemi̇r (ORCID: https://orcid.org/0000-0001-9585-3169)
- Selma Yazıcı (ORCID: https://orcid.org/0009-0009-3289-7346)
- Derya Güzel (ORCID: https://orcid.org/0000-0002-7618-5043)
- Mustafa Can Güler (ORCID: https://orcid.org/0000-0001-8588-1035)
- Ersen Eraslan (ORCID: https://orcid.org/0000-0003-2424-2269)
- Burak Bircan (ORCID: https://orcid.org/0000-0003-1141-069X)
- Ayhan Tanyeli̇ (ORCID: https://orcid.org/0000-0002-0095-0917)
- Elif Polat (ORCID: https://orcid.org/0000-0003-0042-4084)
Institutions
- Sakarya University (TR)
- Osmaniye Korkut Ata University (TR)
- Erzurum Technical University (TR)
- Ağrı İbrahim Çeçen University (TR)
- Bandırma Onyedi Eylül University (TR)
- Erzurum Regional Training and Research Hospital (TR)
- Atatürk University (TR)
Publication Details
- Journal
- Journal of Laboratory Animal Science and Practices
- Published
- 2025-09-19
- DOI
- https://doi.org/10.62425/jlasp.1673052
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81