Progress in the study of the role of C5a-induced tubular cell senescence in the progression of diabetic kidney disease
In the high-glucose milieu, complement activation drives massive C5a release, which accelerates DKD progression by inducing renal tubular cell senescence. C5a-receptor antagonists have already demonstrated potent renoprotective effects, positioning C5a as a central target for future DKD drug development.
Authors
- Changjiang Guo (ORCID: https://orcid.org/0000-0002-7447-3762)
- Xiangling Li (ORCID: https://orcid.org/0000-0002-2765-9708)
- Zhaoyang Fan (ORCID: https://orcid.org/0000-0002-6185-2325)
- Mingjie Chen (ORCID: https://orcid.org/0000-0002-1644-9975)
- Jiaxuan Zhang (ORCID: https://orcid.org/0000-0003-2439-7607)
Institutions
- Weifang Medical University (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1080/07853890.2025.2561232
- Citations
- 4
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.19