Associations Between Blood Heavy Metal Concentrations and Hypertensive Disorders of Pregnancy in the Japan Environment and Children's Study
Higher blood lead, cadmium, and mercury concentrations were associated with HDP in Japanese pregnant women. Our findings suggest that low-dose exposure to these heavy metals is an underrecognized but important risk factor for HDP, highlighting the need to develop measures to reduce heavy metal exposure.
Authors
- Ryoji Shinohara (ORCID: https://orcid.org/0000-0003-1362-0674)
- Koichi Hashimoto (ORCID: https://orcid.org/0000-0002-4473-2698)
- Hidekuni Inadera
- Ryo Kawasaki (ORCID: https://orcid.org/0000-0002-7492-6303)
- Reiko Kishi (ORCID: https://orcid.org/0000-0001-8173-9269)
- Takeo Nakayama (ORCID: https://orcid.org/0000-0002-7918-6252)
- Nobuhisa Morimoto (ORCID: https://orcid.org/0000-0002-8330-002X)
- Chisato Mori (ORCID: https://orcid.org/0000-0002-1144-8316)
- Narufumi Suganuma (ORCID: https://orcid.org/0000-0003-1610-6216)
- Seiji Kageyama (ORCID: https://orcid.org/0000-0002-5220-6137)
- Maki Fukami (ORCID: https://orcid.org/0000-0001-9971-4035)
- Michihiro Kamijima (ORCID: https://orcid.org/0000-0003-0670-8790)
- Shuichi Ito (ORCID: https://orcid.org/0000-0002-5584-1072)
- Yasuhiro Takeshima (ORCID: https://orcid.org/0000-0002-6468-7185)
- Chiharu Ota (ORCID: https://orcid.org/0000-0002-0644-1144)
- Hitomi Okubo (ORCID: https://orcid.org/0000-0002-2305-0719)
- Takahiko Katoh
- Shoichi Ohga
- Shoji F. Nakayama (ORCID: https://orcid.org/0000-0001-7772-0389)
- Shin Yamazaki (ORCID: https://orcid.org/0000-0002-2309-2425)
Institutions
- Bunkyo University (JP)
- National Institute for Environmental Studies (JP)
- St. Luke's International University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1161/jaha.125.042183
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00