Photorelease of Hydrogen Sulfide (H<sub>2</sub>S) from Stable Water-Soluble Precursors
Two hydrogen sulfide photoreleasing molecules (photo-HSRMs), 3-hydroxy-2-naphthalene-methanethiol and the corresponding disulfide, have been synthesized, and their properties and photochemical reactivity have been explored. Both compounds are stable in the neat form and in aqueous solutions in the dark but release H<sub>2</sub>S under exposure to UVA and UVB light in good quantum and chemical yields. In the presence of thiols, such as cysteine, glutathione, and mercaptoethanol, the yield of hydrogen sulfide release reaches 90%. The mechanism of H<sub>2</sub>S photorelease from these photo-HSRMs is discussed.
Authors
- Vladimir V. Popik (ORCID: https://orcid.org/0000-0001-9112-3935)
- Kun Wang (ORCID: https://orcid.org/0000-0002-9533-7452)
Institutions
- University of Georgia (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-19
- DOI
- https://doi.org/10.1021/acs.joc.5c01997
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11